1,2‐Propanediol‐induced changes in plasma and tissue lipids of rats
1978; Wiley; Volume: 13; Issue: 6 Linguagem: Inglês
10.1007/bf02533718
ISSN1558-9307
AutoresM. K. P. Amma, H. M. Dani, Pushpa Ahluwalia, Aruna Dhingra, Jaswinder Kaur, Charanjit Kaur, Sushma Sharma, K.L. Jain, Sarvpreet Singh, K Sareen,
Tópico(s)Cholesterol and Lipid Metabolism
ResumoOral administration of 1,2-propanediol to rats in a daily dose of 1 ml of 28.4% aqueous solution per 100 g body weight for 30 days caused a significant decrease in the total lipids, fatty acids, phospholipids, and triglycerides of plasma, liver, and heart. The cholesterol content in plasma decreased while that in the tissues increased significantly. The accumulation of cholesterol in tissues tends to discourage long term use of 1,2-propanediol even by the oral route.
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