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Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose–response framework

2007; Elsevier BV; Volume: 222; Issue: 1 Linguagem: Inglês

10.1016/j.taap.2007.02.015

1096-0333

Edward J. Calabrese, Kenneth Bachmann, A. John Bailer, P. Michael Bolger, Jonathan Borak, Lu Cai, Nina Cedergreen, M. George Cherian, Chuang C. Chiueh, Thomas W. Clarkson, Ralph R. Cook, David M. Diamond, David J. Doolittle, Michael A. Dorato, Stephen O. Duke, Ludwig E. Feinendegen, Donald E. Gardner, Ronald W. Hart, Kenneth L. Hastings, A. Wallace Hayes, George Hoffmann, John A. Ives, Zbigniew Jaworowski, Thomas E. Johnson, Wayne B. Jonas, Norbert E. Kaminski, John G. Keller, James E. Klaunig, Thomas B. Knudsen, Walter J. Kozumbo, Teresa Lettieri, Shu-Zheng Liu, André Maïsseu, Kenneth I. Maynard, Edward J. Masoro, R.O. McClellan, Harihara M. Mehendale, Carmel Mothersill, David B. Newlin, H. N. Nigg, Frederick W. Oehme, Robert F. Phalen, Martin A. Philbert, Suresh I. S. Rattan, Jim E. Riviere, Joseph V. Rodricks, Robert M. Sapolsky, Bobby R. Scott, Colin Seymour, David Sinclair, Joan Smith‐Sonneborn, Elizabeth T. Snow, Linda P. Spear, Donald E. Stevenson, Y Thomas, Maurice Tubiana, Gary M. Williams, Mark P. Mattson,

Cardiac Ischemia and Reperfusion

Many biological subdisciplines that regularly assess dose–response relationships have identified an evolutionarily conserved process in which a low dose of a stressful stimulus activates an adaptive response that increases the resistance of the cell or organism to a moderate to severe level of stress. Due to a lack of frequent interaction among scientists in these many areas, there has emerged a broad range of terms that describe such dose–response relationships. This situation has become problematic because the different terms describe a family of similar biological responses (e.g., adaptive response, preconditioning, hormesis), adversely affecting interdisciplinary communication, and possibly even obscuring generalizable features and central biological concepts. With support from scientists in a broad range of disciplines, this article offers a set of recommendations we believe can achieve greater conceptual harmony in dose–response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines.