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Antibacterial Activity in Higher Fungi (Mushrooms) and Endophytic Fungi from Slovenia

2007; Taylor & Francis; Volume: 45; Issue: 9 Linguagem: Inglês

10.1080/13880200701575189

1744-5116

Damjan Janeš, Samo Kreft, Maja Jurc, Katja Seme, Borut Štrukelj,

Chemical synthesis and alkaloids

Discovery and development of new antibiotics is still very important because of the constant appearance of drug-resistant pathogenic bacteria. The broth microdilution test was applied for screening of antibacterial activity in extracts of higher and endophytic fungi. Among tested extracts, three possessed significant antibacterial activity: extracts of mushrooms Amanita virosa. (Fr.) Bertill. (Amanitaceae) and Cortinarius praestans. Cordier (Cortinariaceae) against Pseudomonas aeruginosa. and Staphylococcus aureus., respectively, and extract of endophytic fungus Trucatella hartigii. (Tubeuf) Steyaert (Amphisphaeriaceae) against Enterococcus faecalis. and S. aureus.. The extract of Truncatella hartigii. was further analyzed by one- and two-dimensional thin-layer chromatography, and the position of the active compound was determined on the chromatogram.