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T lymphocytes bearing the γδ T-cell receptor: a study in normal human skin and pathological skin conditions

1992; Oxford University Press; Volume: 127; Issue: 5 Linguagem: Inglês

10.1111/j.1365-2133.1992.tb14840.x

1365-2133

Mauro Alaibac, J Morris, Raymond C. Yu, A.C. Chu,

CAR-T cell therapy research

The aims of this study were to investigate the presence of γδ T cells in normal human skin, and the possible role of these cells in cutaneous reactions. Twenty-eight samples of normal skin from various sites, and 52 biopsies from inflammatory and neoplastic skin conditions were investigated by immunohistochemical techniques. In normal human skin γδ T cells were infrequently seen in the epidermis and dermis. In the inflammatory and neoplastic dermatoses, γδ T cells were occasionally present, accounting for 0–5% of CD3+ cells in most of the biopsies examined. In one case of pityriasis lichenoides chronica and one case of lichen planus γδ T cells were found to be increased, accounting for 15% of the CD3+ cells in each case. Dermal γδ T cells were markedly increased in three of six cases of Langerhans cell histiocytosis. with up to 30% of dermal CD3+ cells showing positive staining to an anti-T-cell receptor γδ monoclonal antibody. In two of these cases γδ T cells were seen in both the dermis and the epidermis. In two further cases dermal γδ T cells were not a prominent feature, but small clusters of epidermal γδ T cells were observed. T cells bearing the γδ T-cell receptor are thus not a major feature of normal human epidermis, unlike the murine system, where the great majority of epidermal lymphocytes express the γδ T-cell receptor. The finding of numerous γδ T cells in Langerhans cell histiocytosis suggests a possible functional relationship between γδ T cells and Langerhans cells or possibly a pathogenic role of these cells in Langerhans cell histiocytosis.