Impact of Inoculum Size and Heterogeneous Vancomycin-Intermediate Staphylococcus aureus (hVISA) on Vancomycin Activity and Emergence of VISA in an In Vitro Pharmacodynamic Model
2008; American Society for Microbiology; Volume: 53; Issue: 2 Linguagem: Inglês
10.1128/aac.01009-08
ISSN1098-6596
AutoresWarren E. Rose, Steven N. Leonard, Kerri L. Rossi, Glenn W. Kaatz, Michael J. Rybak,
Tópico(s)Clostridium difficile and Clostridium perfringens research
ResumoThe activity of vancomycin against heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA) and non-hVISA isolates, using an in vitro pharmacodynamic model, was reduced in the presence of a high inoculum amount (10(8) CFU/ml). A high bacterial load of >10(5) CFU/ml persisted for all strains with doses up to 5 g every 12 h against high inoculum amounts. No change in the vancomycin MIC was detected in any isolate at a moderate inoculum amount (10(6) CFU/ml), and bactericidal activity occurred only against the non-hVISA isolate (time to 99% kill, 7.5 h; P = 0.001).
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