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The Milieu Intérieur study — An integrative approach for study of human immunological variance

2015; Elsevier BV; Volume: 157; Issue: 2 Linguagem: Inglês

10.1016/j.clim.2014.12.004

1521-7035

Stéphanie Thomas, Vincent Rouilly, Étienne Patin, Cécile Alanio, Annick Dubois, Cécile Delval, Louis-Guillaume Marquier, Nicolas Fauchoux, Seloua Sayegrih, Muriel Vray, Darragh Duffy, Lluís Quintana‐Murci, Matthew L. Albert, Laurent Abel, Andrés Alcover, Philippe Bousso, Pierre Bruhns, Ana Cumano, Marc Daëron, Cécile Delval, Caroline Demangel, Ludovic Deriano, James P. Di Santo, Françoise Dromer, Gérard Eberl, Jost Enninga, António A. Freitas, Odile Gelpi, Ivo G. Boneca, Serge Hercberg, Olivier Lantz, Claude Leclerc, Hugo Mouquet, Sandra Pellegrini, Stanislas Pol, Lars Rogge, Anavaj Sakuntabhai, Olivier Schwartz, Benno Schwikowski, Spencer Shorte, Vassili Soumelis, Frédéric Tangy, Éric Tartour, Antoine Toubert, Marie-Noëlle Ungeheuer, Lluís Quintana‐Murci, Matthew L. Albert,

Cytomegalovirus and herpesvirus research

The Milieu Intérieur Consortium has established a 1000-person healthy population-based study (stratified according to sex and age), creating an unparalleled opportunity for assessing the determinants of human immunologic variance. Herein, we define the criteria utilized for participant enrollment, and highlight the key data that were collected for correlative studies. In this report, we analyzed biological correlates of sex, age, smoking-habits, metabolic score and CMV infection. We characterized and identified unique risk factors among healthy donors, as compared to studies that have focused on the general population or disease cohorts. Finally, we highlight sex-bias in the thresholds used for metabolic score determination and recommend a deeper examination of current guidelines. In sum, our clinical design, standardized sample collection strategies, and epidemiological data analyses have established the foundation for defining variability within human immune responses.