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Chemical compositions and anti-influenza activities of essential oils from Mosla dianthera

2011; Elsevier BV; Volume: 139; Issue: 2 Linguagem: Inglês

10.1016/j.jep.2011.11.056

1872-7573

WU Qiao-feng, Wei Wang, Xiao-Yan Dai, Zhiyuan Wang, Zhenhua Shen, Huazhong Ying, Chen-Huan Yu,

Phytochemistry and Biological Activities

Mosla dianthera as an aromatic herb is used in folk medicine for the treatment of cough, colds, fever, bronchitis, nasal congestion and headache. To characterize chemical compositions and to evaluate the anti-influenza effects of essential oils of M. dianthera (MDEO) in influenza virus A (IVA) infected mice. MDEO was obtained by hydrodistillation and analysed by gas chromatography–mass spectrometry (GC–MS). ICR mice were treated with MDEO for 5 consecutive days at doses of 90–360 mg/kg after post-infected. Levels of Serum IL-4 and IFN-γ were assayed by ELISA. Levels of MOD, SOD, TAOC and GSH-Px in lung tissue were determined by colorimetric method. GC–MS analysis revealed the presence of 29 components that account for 97.74% of phenolic sesquiterpenes and aromatic compounds. The major compounds were elemicin (16.51%), thymol (14.77%), β-caryophyllene (14.49%), iso-elemicin (9.22%), asarone (6.09%) and α-caryophyllene (5.26%). It had significant effects on decreasing lung viral titers, inhibiting pneumonia, reducing levels of serum IFN-γ and IL-4, and enhancing antioxidant activity in the lung tissue of IVA infected mice. MPE could exhibit therapeutical effects in IVA infected mice as a suppressor of IVA replication and inflammatory mediators and a promoter of antioxidant potentials. Therefore, MDEO could provide a safe and effective therapeutic candidate for treatment of influenza and its subsequent viral pneumonia.