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Synthesis of Acridines by the [4 + 2] Annulation of Arynes and 2-Aminoaryl Ketones

2010; American Chemical Society; Volume: 75; Issue: 7 Linguagem: Inglês

10.1021/jo1000687

1520-6904

Donald C. Rogness, Richard C. Larock,

Synthesis and Biological Activity

The reaction of 2-aminoaryl ketones and arynes generated by the treatment of various o-(trimethylsilyl)aryl triflates with CsF results in [4 + 2] annulation to afford substituted acridines in good yields.