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128-Channel EEG Source Imaging in Epilepsy: Clinical Yield and Localization Precision

2004; Lippincott Williams & Wilkins; Volume: 21; Issue: 2 Linguagem: Inglês

10.1097/00004691-200403000-00001

1537-1603

Christoph M. Michel, Göran Lantz, Laurent Spinelli, Rolando Grave de Peralta, Théodor Landis, Margitta Seeck,

Advanced MRI Techniques and Applications

The authors evaluated the feasibility, clinical yield, and localization precision of high-resolution EEG source imaging of interictal epileptic activity. A consecutive series of 44 patients with intractable epilepsy of various causes, who underwent a comprehensive presurgical epilepsy evaluation, were subjected to a 128-channel EEG recording. A standardized source imaging procedure constrained to the individual gray matter was applied to the averaged spikes of each patient. In 32 patients, the presurgical workup identified a focal epileptogenic area. The 128-channel EEG source imaging correctly localized this area in 30 of these patients (93.7%). Imprecise localization was explained by simplifications of the recordings and analysis procedure, which was accepted for the benefit of speed and standardization. In a subgroup of 24 patients who underwent operations, the sublobar precision of the 128-channel EEG source imaging was evaluated by calculating the distance of the source maximum to the resected area. This analysis revealed zero distance in 19 cases (79%). The authors conclude that high-resolution interictal EEG source imaging is a valuable noninvasive functional neuroimaging technique. The speed, ease, flexibility, and low cost of this technique warrant its use in clinical practice.