Effect of polyamines on the metabolism of [16-14C]estradiol by rat-liver microsomes
1967; Elsevier BV; Volume: 137; Issue: 2 Linguagem: Inglês
10.1016/0005-2760(67)90112-9
ISSN1879-145X
AutoresPeter H. Jellinck, Gloria R. Perry,
Tópico(s)DNA and Nucleic Acid Chemistry
ResumoThe polyamines, spermine and spermidine, produced a marked increase in the conversion of [14C]estradiol to water-soluble metabolites when added in vitro to rat-liver microsomal preparations. Other aliphatic amines had little or no effect while some aromatic amines were inhibitory. Spermine and spermidine also increased the production of 2-hydroxyestradiol but the percentage of the water-soluble products bound to protein was not altered and no effect on estrogen metabolism was observed when these polyamines were added to liver slices or administered in vivo. It is proposed that spermine and spermidine act by stabilizing microsomal components involved in aromatic hydroxylation.
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