An efficient copper-catalyzed coupling of aryl halides with imidazoles
1999; Elsevier BV; Volume: 40; Issue: 14 Linguagem: Inglês
10.1016/s0040-4039(99)00291-9
ISSN1873-3581
AutoresAyumu Kiyomori, Jean-François Marcoux, Stephen L. Buchwald,
Tópico(s)Catalytic C–H Functionalization Methods
ResumoCopper-catalyzed N-arylation of imidazoles can be accomplished using (CuOTf)2·benzene as a copper source and Cs2CO3 as a base in xylenes at 110–125 °C. Addition of 1,10-phenanthroline (phen) and trans,trans-dibenzylideneacetone (dba) was crucial to the success of the process. The products, N-arylimidazoles, were isolated in high yields.
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