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Effect of 2,3-DPG Concentration on Hemoglobin-Oxygen Affinity of Whole Blood

1969; Taylor & Francis; Volume: 24; Issue: 4 Linguagem: Inglês

10.3109/00365516909080180

1502-7686

Gabriel Duc, K. Engel,

Nitric Oxide and Endothelin Effects

The influence of 2,3-diphosphoglycerate concentration (DPG) on hemoglobin-oxygen affinity (P50) in whole blood from adults and newborns has been studied. In blood from adults a decrease in DPG of 0.61 mol DPG/mol Hb is associated with a decrease in P50 of 13 mm Hg. In samples from newborns a decrease in DPG of 0.95 mol/mol Hb is associated with a decrease in P50 of 4.7 mm Hg. This difference may be due to a lesser affinity of fetal hemoglobin for DPG, and/or to the effect of DPG on the adult hemoglobin present in newborn blood.