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An empirical hydrophobicity scale for α-amino-acids and some of its applications

1971; Elsevier BV; Volume: 2; Issue: 11 Linguagem: Inglês

10.1016/0020-711x(71)90023-1

1878-6014

Akintola A. Aboderin,

Computational Drug Discovery Methods

1. Hydrophobicity indices for α-amino-acids are derived from the relative mobilities of α-N-(4-nitrobenzofurazano)-amino-acids (NBD-amino-acids) on paper chromatograms with the solvent system ethyl acetate/pyridine/water, 8:2:1 (v/v). 2. The indices are algebraic sums of hydrophobicity contributions of functional groups, δHf, present in the side chain. 3. Using the scale, amino-acid replacement matrices have been constructed and used to discuss aspects of the problem of structural homology in proteins.