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BIBTEX RIS

Estudo, ao microscópio óptico e eletrônico, do rim de caes natural e experimentalmente infectados com Leishmania (Leishmania) chagasi

1989; UNIVERSIDADE DE SÃO PAULO; Volume: 31; Issue: 3 Linguagem: Inglês

10.1590/s0036-46651989000300002

ISSN

1678-9946

Autores

Washington Luíz Tafuri, Marilena Suzan Marques Michalick, Magno Dias, Odair Genaro, Virgínia Hora Rios Leite, Alfredo José Afonso Barbosa, Eduardo Alves Bambirra, Carlos Alberto da Costa, Maria Norma Melo, Wilson Mayrink,

Tópico(s)

Trypanosoma species research and implications

Resumo

Two naturally infected dogs (male and female) from Teófilo Otoni (MG-Brazil) were maintained for 18 months in our laboratory. Two other dogs, two months old males were infected with 1 x 10(6) promastigotes of MHO/BR/70/BH46 Leishmania (Leishmania) chagasi strain, endovenous route, and autopsied after 10 months and two years. The main findings concerning the kidney were: (1) focal or diffuse mesangial glomerulonephritis with proliferative and enlargement of mesangial cells; (2) increase in thickness of basement membrane with electron-dense deposits; (3) chronic interstitial nephritis with intense exudation of plasmocytes; (4) cloud swelling of renal tubules. The authors discuss the probable pathogenetic mechanisms.

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