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BIBTEX RIS

Importance of Early Absolute Lymphocyte Count After Allogeneic Stem Cell Transplantation: A Retrospective Study

2015; Elsevier BV; Volume: 47; Issue: 2 Linguagem: Inglês

10.1016/j.transproceed.2014.11.042

1873-2623

Lisandra Della Costa Rigoni, Maria Lúcia Scroferneker, Beatriz Stela Pitombeira, Erica Lammerhirt Ottoni, Alessandra Aparecida Paz, Gilberto Bueno Fischer, Mariana Bohns Michalowski, Annelise Pezzi, Barbara Juarez Amorin, Vanessa de Souza Valim, Letícia Baggio, Álvaro Macedo Laureano, M.A. da Silva, Lúcia Mariano da Rocha Silla, Liane Esteves Daudt,

Neutropenia and Cancer Infections

Early lymphocyte recovery after allogeneic hematopoietic stem cell transplantation (HSCT) is related to the prevention of serious infections and the clearing of residual tumor cells. We analyzed the absolute lymphocyte count at 20 (D+20) and 30 (D+30) days after HSCT in 100 patients with malignant hematologic diseases and correlated with the risk of transplant-related mortality, overall survival (OS), disease-free survival (DFS), nonrelapsed mortality (NRM), and risk of infection. Patients presenting with lymphocyte counts of <300 × 103/μL on D+30 have a 3.76 times greater risk of death in <100 days. Over a medium follow-up of 20 months OS, DFS, and NRM were similar between the groups. In our group of patients delayed lymphocyte recovery after HSCT was a predictor of early death post-HSCT.