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Evidence for quasi‐silent germline genes coding for phylogenetically ancient determinants of the rabbit a locus allotypes

1977; Wiley; Volume: 7; Issue: 1 Linguagem: Inglês

10.1002/eji.1830070105

1521-4141

Wessel van der Loo, P. De Baetseliei, C. Hamers‐Casterman, R. Hamers,

Pharmacological Effects of Natural Compounds

Abstract Anti‐a 2 sera raised in a3 rabbits are shown to detect determinants on a2 molecules which are different from those detected by anti‐a 2 sera raised in al animals. The former determinants are occasionally observed at a low level in rabbits of the al allotype and at a high level in sera of Leporidae of different genera. The two types of anti‐a 2 sera are shown to compete for the same sterical region of the a2 molecules. All homogeneous a2 molecules which have been tested show both types of determinants.