Aspirin—a national survey II: Determination of salicylic acid in bulk aspirin and aspirin formulations by high-pressure liquid chromatography using a fluorescence detector
1980; Elsevier BV; Volume: 69; Issue: 5 Linguagem: Inglês
10.1002/jps.2600690518
ISSN1520-6017
AutoresRoss D Kirchhoefer, William E. Juhl,
Tópico(s)Inflammatory mediators and NSAID effects
ResumoA quantitative high-pressure liquid chromatographic method, using a reversed-phase column coupled to a fluorescence detector, was developed to determine salicylic acid in bulk aspirin and plain and buffered aspirin tablets. The aspirin was dissolved, filtered, and injected into the chromatograph; the fluorescence of the salicylic acid was measured at approximately 425 nm. Excipients and impurities did not interfere, and recoveries of 100% were obtained. The method was used to analyze 84 aspirin samples.
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