7-Silylcamptothecins (silatecans): A new family of camptothecin antitumor agents
1997; Elsevier BV; Volume: 7; Issue: 24 Linguagem: Inglês
10.1016/s0960-894x(97)10181-0
ISSN1464-3405
AutoresHubert Josien, David Bom, Dennis P. Curran, Yu‐Huang Zheng, Ting‐Chao Chou,
Tópico(s)Synthetic Organic Chemistry Methods
ResumoThe synthesis and biological evaluation of about one dozen 7-silylcamptothecin derivatives are described. Most new compounds show potencies comparable to or better than camptothecin itself. The best compound, 11-fluoro-10-amino-7-trimethylsilylcamptothecin, is more than 20 times more potent than camptothecin in cell assays.
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