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An MF59-adjuvanted inactivated influenza vaccine containing A/Panama/1999 (H3N2) induced broader serological protection against heterovariant influenza virus strain A/Fujian/2002 than a subunit and a split influenza vaccine

2006; Elsevier BV; Volume: 24; Issue: 16 Linguagem: Inglês

10.1016/j.vaccine.2006.01.015

1873-2518

Giuseppe Lo Giudice, Anke Hilbert, Roberto Bugarini, Ada Minutello, О. Н. Попова, Daniela Toneatto, Ines Schoendorf, Astrid Borkowski, Rino Rappuoli, Audino Podda,

Animal Disease Management and Epidemiology

To test whether inactivated influenza vaccines distributed during the 2003–2004 influenza season in the northern hemisphere were able to confer protection against the mismatched variant A/Fujian/411/2002 virus strain, we measured haemagglutination inhibiting (HI) antibodies in elderly subjects vaccinated with three inactivated vaccines against the homologous A/H3N2 vaccine strain (A/Panama) and against the mismatched A/Fujian strain. The results showed that, while 76 to 80% of elder people vaccinated with conventional vaccines had protected levels of antibodies against the A/Fujian heterovariant strain, those vaccinated with the MF59-adjuvanted vaccine have protective levels of antibodies in >98% of the cases. We conclude that MF59-adjuvanted vaccines confer protection also against influenza virus strains which are not fully matched with those included in the vaccine.