Produção Nacional
Long-term Survival Rates in Young Patients With Thyroid Carcinoma
2003; American Medical Association; Volume: 129; Issue: 7 Linguagem: Inglês
10.1001/archotol.129.7.746
ISSN1538-361X
AutoresLuiz Paulo Kowalski, João Gonçalves Filho, Clóvis Antônio Lopes Pinto, André Lopes Carvalho, Beatriz de Camargo,
Tópico(s)Global Cancer Incidence and Screening
ResumoBackground: Thyroid carcinoma in patients younger than 18 years is rare.It is associated with a greater risk of metastases.However, the prognosis for these patients is better when compared with that of adults.Objective: To present the experience of a single institution in the treatment of patients with thyroid carcinoma during childhood and adolescence.Patients and Methods: Thirty-eight patients, ranging in age from 4 to 18 years, were diagnosed as having thyroid carcinoma.Pathologic types of carcinoma included 29 papillary, 4 follicular, 1 Hu ¨rthle cell, and 4 medullary cases.Results: Hypocalcemia was the main complication, being transitory in 9 patients (24%) and permanent in 6 patients (16%).Vocal cord palsy occurred in 2 patients (5%).Two patients (5%) had a surgical site infection.After a mean follow-up of 9.5 years (range, 1-40 years), 28 patients (74%) were alive and had no evidence of disease, 3 (8%) were alive and had recurrent disease, 4 (11%) died (2 of the disease and 2 of non-cancer-related causes), and 3 (8%) were lost to follow-up.The survival rates at 10 years for the patients with papillary, follicular, and medullary carcinoma were 93%, 100%, and 50%, respectively.Conclusions: Thyroid carcinoma in patients younger than 18 years has a good prognosis even in the presence of neck or distant metastasis.Total thyroidectomy, associated with adjuvant radioactive iodine therapy and thyroidal suppression or not, is effective in patients with a well-differentiated thyroid carcinoma.
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