Fetal swallowing of IgE
1998; Elsevier BV; Volume: 351; Issue: 9119 Linguagem: Inglês
10.1016/s0140-6736(05)78805-x
ISSN1474-547X
AutoresCatherine A. Jones, Jill A. Warner, John O. Warner,
Tópico(s)Eosinophilic Esophagitis
ResumoAllergic disease is more frequently manifest by the offspring of atopic mothers than atopic fathers. Furthermore, newborn umbilical-cord blood mononuclear cells exhibit allergen specific proliferation predicting subsequent allergic disease. Thus, intrauterine exposure to allergen and the development of immunological memory must occur in the fetus and be influenced by maternal health and environment. The key question is how does fetal-allergen exposure and sensitisation occur? Because increased IgE is a hallmark of allergy and can mediate allergen uptake via IgE receptor-mediated antigen focusing, 1 Maurer D Ebner C Reininger B The high affinity IgE receptor (FceRI) mediates IgE-dependent allergen presentation. J Immunol. 1995; 154: 6285-6290 PubMed Google Scholar we evaluated whether the fetus was exposed to IgE during life in utero.
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