Iodine-Mediated α-Acetoxylation of 2,3-Disubstituted Indoles
2012; American Chemical Society; Volume: 14; Issue: 23 Linguagem: Inglês
10.1021/ol302983t
ISSN1523-7060
AutoresHisaaki Zaimoku, Takashi Hatta, Tsuyoshi Taniguchi, Hiroyuki Ishibashi,
Tópico(s)Synthesis and Catalytic Reactions
ResumoA new method for direct α-functionalization of 2,3-disubstituted indoles has been developed. The present reaction provides α-acetoxy indole derivatives regioselectively under mild conditions using commercially available and nontoxic iodine reagents. This reaction is a useful synthetic tool because obtained α-acetoxy products can be transformed into various functionalized indoles by substitution reactions with nucleophiles.
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