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Models of HIV-1 disease: A review of current status

2006; Elsevier BV; Volume: 3; Issue: 1 Linguagem: Inglês

10.1016/j.ddmod.2006.03.016

1740-6757

Cheryl A. Stoddart, Richard A. Reyes,

HIV/AIDS Research and Interventions

There is an urgent need for more effective drugs to treat HIV-1 infection and AIDS, in particular new compounds with activity against virus resistant to currently licensed antiretrovirals. Drug resistance occurs in >50% of patients on antiretroviral therapy and is the leading cause of treatment failure. The highly specific tropism of HIV-1 for human cells makes disease modeling a considerable challenge. To address this challenge, several models have been developed enabling greater insight into disease pathogenesis and more efficient evaluation of new therapies.