Chemical and biological characterization of a series of water soluble 1,2-diaminocyclohexane platinum(II) complexes
1991; Elsevier BV; Volume: 179; Issue: 2 Linguagem: Inglês
10.1016/s0020-1693(00)85890-9
ISSN1873-3255
AutoresAbdul R. Khokhar, Miles P. Hacker,
Tópico(s)Magnetism in coordination complexes
ResumoA series of water soluble 1,2-diaminocyclohexane platinum(II) complexes have been synthesized and analyzed for their mode of ligand coordination and biological activity. Preliminary in vitro and in vivo screening tests indicate that these complexes have excellent antitumor activity and ere not cross-resistant with DDP. These results suggest that this series of platinum complexes warrant further study for eventual introduction into clinical studies.
Referência(s)