Portal de Periódicos da CAPES

PET/CT imaging in response evaluation of patients with small cell lung cancer

2006; Elsevier BV; Volume: 54; Issue: 1 Linguagem: Inglês

10.1016/j.lungcan.2006.06.012

1872-8332

Barbara Malene Fischer, Jann Mortensen, Seppo W. Langer, Annika Loft, Anne Kiil Berthelsen, Gedske Daugaard, Ulrik Lassen, Heine H. Hansen,

Lung Cancer Treatments and Mutations

There is an increasing amount of evidence on the usability of PET in response evaluation of non-small cell lung cancer. However, data on SCLC is scarce and mainly retrospective. This prospective study assesses the use of PET (positron emission tomography) and PET/CT in response evaluation of patients with small cell lung cancer (SCLC). Methods Assignment of early and final response was compared between PET, PET/CT, and CT in 20 patients with SCLC. Final response as assigned by CT (RECIST) served as reference. Results At response evaluation after one cycle of chemotherapy major disagreement (responder versus non-responder) between PET and CT in predicting final response was seen in 1 of 12 patients. At final response evaluation major disagreement between PET, PET/CT and CT was seen in 2 of 19 patients (11%). All measurements of FDG-uptake were significantly correlated to size and changes in size as measured by CT. A significant difference in relative change in tumour FDG-uptake and volume was found between responding and non-responding patients. No significant difference was found between a visual and semi-quantitative analysis of PET. Conclusion Response evaluation of SCLC by PET/CT is feasible, but it is uncertain whether it adds further information to evaluation by RECIST, thus further studies and standardization of methods are needed.