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Revisão Revisado por pares
BIBTEX RIS

Homer proteins: implications for neuropsychiatric disorders

2006; Elsevier BV; Volume: 16; Issue: 3 Linguagem: Inglês

10.1016/j.conb.2006.05.002

ISSN

1873-6882

Autores

Karen K. Szumlinski, Peter W. Kalivas, Paul F. Worley,

Tópico(s)

Genetic Neurodegenerative Diseases

Resumo

Homer proteins regulate signal transduction, synaptogenesis and receptor trafficking, in addition to maintaining and regulating extracellular glutamate levels in limbo–corticostriatal brain regions. Converging preclinical observations indicate a potential role for both immediate early gene Homer isoforms and constitutively expressed Homer isoforms in behavioral pathologies associated with neuropsychiatric disorders, such as addiction and/or alcoholism, depression, anxiety, epilepsy and schizophrenia.

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