New synthesis of β-amino acids by nucleophilic addition of enolate anions to N-methoxycarbonylimines generated from α-methoxy carbamates1
1988; Elsevier BV; Volume: 29; Issue: 2 Linguagem: Inglês
10.1016/s0040-4039(00)80062-3
ISSN1873-3581
AutoresTatsuya Shono, Naoki Kise, Fumio Sanda, Satoru Ohi, Kenji Tsubata,
Tópico(s)Asymmetric Hydrogenation and Catalysis
ResumoThe nucleophilic addition of enolate anions of alkyl acetates to N-methoxycarbonylimines generated from α-methoxy carbamates gave β-amino acid derivatives (3) and enantioselective synthesis (72-90%ee) of 3 was achieved by using chiral 2-methyloxazolines instead of acetates.
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