Produção Nacional
Revisado por pares
New Pd(II) and Pt(II) complexes with N,S-chelated pyrazolonate ligands: Molecular and supramolecular structure and preliminary study of their in vitro antitumoral activity
2007; Elsevier BV; Volume: 102; Issue: 1 Linguagem: Inglês
10.1016/j.jinorgbio.2007.06.032
ISSN1873-3344
AutoresJosé S. Casas, E.E. Castellano, Javier Ellena, M.S. Garcı́a-Tasende, M. Luz Pérez‐Parallé, A. Sánchez, A. Sánchez-González, J. Sordo, A. Touceda,
Tópico(s)Synthesis and Reactions of Organic Compounds
ResumoNew Pd(II) and Pt(II) complexes [ML2] (HL = a substituted 2,5-dihydro-5-oxo-1H-pyrazolone-1-carbothioamide) have been synthesized by reacting K2MCl4 (M = Pd, Pt) or Pd(OAc)2 with β-ketoester thiosemicarbazones. The structures of seven of these complexes were determined by X-ray diffraction. Although all exhibit a distorted square-planar coordination with trans- or (in one case) cis-[MN2S2] kernels, their supramolecular arrangements vary widely from isolated molecules to 3D-networks. The in vitro antitumoral assays performed with two HL ligands and their metal complexes showed significant cytostatic activity for the latter, with the most active [ML2] derivative (a palladium complex) being about sixteen times more active than cis-DDP against the cisplatinum-resistant cell line A2780cisR.
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