Molecular determinants of the alpha-2D adrenergic receptor subtype
1993; Elsevier BV; Volume: 53; Issue: 17 Linguagem: Inglês
10.1016/0024-3205(93)90600-8
ISSN1879-0631
AutoresHoward S. Blaxall, Donald A. Heck, David B. Bylund,
Tópico(s)Neuropeptides and Animal Physiology
ResumoThe alpha-2 adrenergic receptor in the bovine pineal gland and the rodent homologues of the human alpha-2-C10 receptor express alpha-2D subtype pharmacological characteristics. The alpha-2 adrenergic receptor in the chicken pineal expresses characteristics similar to the alpha-2A subtype found in human and pig. The rodent receptors (alpha-2D) contain a serine residue at position 201 whereas the human and porcine receptors (alpha-2A) have a cysteine at this position. Our results indicate that the bovine pineal receptor has a serine at position 201, supporting the alpha-2D classification. However, the chicken pineal receptor also contains a serine at position 201 suggesting that other amino acids may be responsible for the differences in pharmacological characteristics.
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