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Antifungal diterpenoids of Pseudolarix kaempferi, and their structure–activity relationship study

2003; Elsevier BV; Volume: 11; Issue: 21 Linguagem: Inglês

10.1016/s0968-0896(03)00531-5

1464-3391

Sheng‐Ping Yang, Lei Dong, Ying Wang, Yan Wu, Jian‐Min Yue,

Phytochemical compounds biological activities

The in vitro antifungal activities of 19 structurally diversified analogues of pseudolaric acids tested against the major pathogenic fungus Candida albicans has led to the establishment of a very clear structure–activity relationship of pseudolaric acids derivatives. Pseudolaric acid A was first found to be a potent antifungal component comparable with pseudolaric acid B. Among the tested 19 diterpenoids, pseudolaric acids A2 (1), B2 (3), B3 (4) and methyl pseudolarate A2 (2) are new isolates of the root bark of Pseudolarix kaempferi, and their structures were elucidated mainly by 2D-NMR techniques and chemical methods. Compounds 12–19 were first semi-synthesized by efficient routines from pseudolaric acid B.