Repeated exposure of C57B1 mice to inhaled benzene at 10 ppm markedly depressed erythropoietic colony formation
1984; Elsevier BV; Volume: 20; Issue: 3 Linguagem: Inglês
10.1016/0378-4274(84)90169-3
ISSN1879-3169
AutoresKeith A. Baarson, C A Snyder, Roy E. Albert,
Tópico(s)Animal testing and alternatives
ResumoExposure of C57B1 mice to 10 ppm benzene (the current occupational exposure limit) for 6 h/day, 5 days/week causes a progressive depression in the in vitro colony forming ability of one of the erythroid progenitor cells, the colony-forming unit-erythroid (CFU-E). Colony growth of cells from exposed mice was only 5% of control colony growth after 178 days of exposure. Burst-forming-cell growth was depressed to 55% of control growth after 66 days but returned to control growth values at 178 days. In addition, benzene-exposed mice exhibited depressions in the numbers of splenic nucleated red cells and in the numbers of circulating red cells and lymphocytes. These results suggest that low-level exposure to benzene may be hematotoxic.
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