A comparison of the pharmacodynamics of rocuronium and vecuronium during halothane anaesthesia
1992; Wiley; Volume: 47; Issue: 10 Linguagem: Inglês
10.1111/j.1365-2044.1992.tb03139.x
ISSN1365-2044
AutoresM. G. Booth, B. T. Marsh, F. Bryden, E. N. Robertson, W.L.M. BAIRD,
Tópico(s)Nausea and vomiting management
ResumoSummary Thirty healthy patients were randomised to receive either a single bolus dose of rocuronium 0.6mg.kg −1 or vecuronium 0.1 mg.kg −1 during halothane anaesthesia. Onset time, duration 25, duration 75 and train‐of‐four 70 were measured. The onset of neuromuscular blockade following rocuronium was more rapid than vecuronium (p = 0.0001). All other pharmacodynamic parameters were similar. During the first minute following injection of the neuromuscular blocking agent, the heart rate increased by 36% in the rocuronium group but remained stable in those patients who received vecuronium (p = 0.0008). No adverse effects were noted in either group.
Referência(s)