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Effect of catecholamines on oedema induced by inflammatory agents in the rat

1979; Elsevier BV; Volume: 57; Issue: 4 Linguagem: Inglês

10.1016/0014-2999(79)90500-4

1879-0712

Gayle O'Duffy, Loris A. Chahl,

Pharmacological Effects of Natural Compounds

The effect of intracutaneous adrenaline and noradrenaline (5 × 10−12 and 5 × 10−11 mol) was examined on the oedema (Evans blue dye leakage) response of rats to several inflammatory agents. The catecholamines reduced the oedema response to all agents tested except prostaglandin E1 (PGE1) which was significantly potentiated by noradrenaline (5 × 10−11 mol), and a combination of bradykinin 5 × 10−11 mol with PGE1 5 × 10−10 mol which was not significant affected by any dose of catecholamine. Adrenaline was more effective than noradrenaline in reducing oedema produced by 5-hydroxytryptamine (5HT) and histamine and by agents which release these amines (compound 4880, dextran and antigen challenge with egg albumin in sensitized rats), but not noradrenaline was more potent against bradykinin-induced oedema. The inhibitory effect of catecholamines against oedema produced by histamine and 5HT was abolished by a combination of phentolamine and propranolol. It was concluded that the oedema-inhibiting effect of catecholamines is due to α- and β-adrenoreceptor mediated actions.