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The Efficacy of Subcutaneous Goretex Implants in Monitoring Wound Healing Response in Experimental Protein Deficiency

1988; Taylor & Francis; Volume: 17; Issue: 3 Linguagem: Inglês

10.3109/03008208809015027

1607-8438

David Haydock, Michael H. Flint, Karena F. Hyde, H. Christine Reilly, Charles Poole, Graham L. Hill,

Muscle activation and electromyography studies

This combined biochemical and histological study demonstrated that subcutaneously implanted Goretex tubing can be used to monitor and detect variations in wound healing potential in rats subjected to experimental hypoproteinaemic and normal refeeding conditions. Induced hypoproteinaemia was observed to be associated with a marked diminution in cellular infiltration, collagen synthesis and fibrous deposition within the implant. All these effects were completely reversed by subsequent refeeding of normal diet. Although regional variations in fibroblastic response attributable to biologic variability, were observed within individual control implants, or between paired controls, they were relatively minor as compared to the marked differences observed at the macroscopic, microscopic and biochemical level between implants removed from normally fed and protein deficient animals.