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Paradoxical Hypersecretion of Growth Hormone in Patients with Endometrial Atypical Hyperplasia and Carcinoma

1982; Karger Publishers; Volume: 13; Issue: 1 Linguagem: Inglês

10.1159/000299479

1423-002X

Daniel Ayalon, Reuben Peyser, Rodica Limor, Joseph B. Lessing, Roma Ravid,

Growth Hormone and Insulin-like Growth Factors

Paradoxical hypersecretion of human growth hormone (HGH) followed a glucose load in patients with endometrial cancer and atypical hyperplasia of the endometrium. All patients had normal fasting plasma glucose and serum HGH concentration with a normal glucose tolerance curve. Their urinary estrogen concentrations were within the normal postmenopausal range. 6 months after abdominal total hysterectomy and bilateral oophorectomy, the glucose load was repeated. Following surgery all patients showed a normal suppression of HGH secretion during the hyperglycemic period. These findings suggest the existence of a HGH-releasing factor in the neoplastic and preneoplastic endometrial tissue. This factor might be related to the abnormal HGH responses observed.