Portal de Periódicos da CAPES

Interactions of Small Protected Peptides with Aminopyrazole Derivatives: The Efficiency of Blocking a β‐Sheet Model in the Gas Phase

2008; Wiley; Volume: 48; Issue: 5 Linguagem: Inglês

10.1002/anie.200802396

1521-3773

Holger Fricke, Andreas Gerlach, C. Unterberg, Mark Wehner, Thomas Schräder, Markus Gerhards,

Monoclonal and Polyclonal Antibodies Research

Angewandte Chemie International EditionVolume 48, Issue 5 p. 900-904 Communication Interactions of Small Protected Peptides with Aminopyrazole Derivatives: The Efficiency of Blocking a β-Sheet Model in the Gas Phase† Holger Fricke Dr., Holger Fricke Dr. Physikalische und Theoretische Chemie, TU Kaiserslautern and Research Center OPTIMAS, Erwin-Schrödinger-Strasse 52, 67633 Kaiserslautern (Germany), Fax: (+49) 631-205-2750Search for more papers by this authorAndreas Gerlach Dr., Andreas Gerlach Dr. Physikalische und Theoretische Chemie, TU Kaiserslautern and Research Center OPTIMAS, Erwin-Schrödinger-Strasse 52, 67633 Kaiserslautern (Germany), Fax: (+49) 631-205-2750Search for more papers by this authorClaus Unterberg Dr., Claus Unterberg Dr. Physikalische und Theoretische Chemie, TU Kaiserslautern and Research Center OPTIMAS, Erwin-Schrödinger-Strasse 52, 67633 Kaiserslautern (Germany), Fax: (+49) 631-205-2750Search for more papers by this authorMark Wehner Dr., Mark Wehner Dr. Institut für Organische Chemie, Universität Duisburg-Essen, Universitätsstrasse 5, 45117 Essen (Germany)Search for more papers by this authorThomas Schrader Prof. Dr., Thomas Schrader Prof. Dr. Institut für Organische Chemie, Universität Duisburg-Essen, Universitätsstrasse 5, 45117 Essen (Germany)Search for more papers by this authorMarkus Gerhards Prof. Dr., Markus Gerhards Prof. Dr. gerhards@chemie.uni-kl.de Physikalische und Theoretische Chemie, TU Kaiserslautern and Research Center OPTIMAS, Erwin-Schrödinger-Strasse 52, 67633 Kaiserslautern (Germany), Fax: (+49) 631-205-2750Search for more papers by this author Holger Fricke Dr., Holger Fricke Dr. Physikalische und Theoretische Chemie, TU Kaiserslautern and Research Center OPTIMAS, Erwin-Schrödinger-Strasse 52, 67633 Kaiserslautern (Germany), Fax: (+49) 631-205-2750Search for more papers by this authorAndreas Gerlach Dr., Andreas Gerlach Dr. Physikalische und Theoretische Chemie, TU Kaiserslautern and Research Center OPTIMAS, Erwin-Schrödinger-Strasse 52, 67633 Kaiserslautern (Germany), Fax: (+49) 631-205-2750Search for more papers by this authorClaus Unterberg Dr., Claus Unterberg Dr. Physikalische und Theoretische Chemie, TU Kaiserslautern and Research Center OPTIMAS, Erwin-Schrödinger-Strasse 52, 67633 Kaiserslautern (Germany), Fax: (+49) 631-205-2750Search for more papers by this authorMark Wehner Dr., Mark Wehner Dr. Institut für Organische Chemie, Universität Duisburg-Essen, Universitätsstrasse 5, 45117 Essen (Germany)Search for more papers by this authorThomas Schrader Prof. Dr., Thomas Schrader Prof. Dr. Institut für Organische Chemie, Universität Duisburg-Essen, Universitätsstrasse 5, 45117 Essen (Germany)Search for more papers by this authorMarkus Gerhards Prof. Dr., Markus Gerhards Prof. Dr. gerhards@chemie.uni-kl.de Physikalische und Theoretische Chemie, TU Kaiserslautern and Research Center OPTIMAS, Erwin-Schrödinger-Strasse 52, 67633 Kaiserslautern (Germany), Fax: (+49) 631-205-2750Search for more papers by this author First published: 13 January 2009 https://doi.org/10.1002/anie.200802396Citations: 17 † We thank the Deutsche Forschungsgemeinschaft (DFG, GE 961/3-3) for financial support and the Rechenzentren der Heinrich-Heine-Universität Düsseldorf and especially the Universität zu Köln for the granted computer time. This work is part of the Ph.D. thesis of H. Fricke. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Binding motifs of aminopyrazole derivatives with different peptides in the gas phase are investigated by using mass- and isomer-selective IR/UV spectroscopy. The efficiency of blocking a β-sheet model is determined by analyzing the number and strength of hydrogen bonds (see picture). The investigations yield information on intrinsic molecular properties of beginning aggregation behavior, as might also occur in misfolding diseases. Citing Literature Volume48, Issue5January 19, 2009Pages 900-904 RelatedInformation