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An Animal Model for Small-Diameter Arterial Grafts

1989; Taylor & Francis; Volume: 2; Issue: 2 Linguagem: Inglês

10.3109/08941938909015349

1521-0553

William Cassel, Richard Mason, Ruth E. Campbell, G. Broadie Newton, John C.K. Hui, Fabio Giron,

Aortic aneurysm repair treatments

A rabbit model was developed to study small-diameter arterial grafts. A total of 158 2-mm-diameter polytetrafluoroethylene (PTFE) grafts and 35 autogenous carotid artery (AA) grafts were interposed in the carotid arteries of New Zealand white rabbits. A pilot study of 16 PTFE grafts used to develop operative and anesthetic techniques had a 20% mortality and 38% early (less than 2 day) thrombosis rate. Subsequent to the pilot study 177 grafts were placed and a 92% postoperative survival with 100% AA graft patency and 93% PTFE graft patency at 2 weeks was observed. AA grafts followed beyond 16 weeks continued to have 100% patency, while PTFE grafts began to show increased failure. Closure was found to be due to the development of anastomotic myointimal hyperplasia.