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The role of human and viral cytokines in the pathogenesis of multiple myeloma

2000; Elsevier BV; Volume: 10; Issue: 5 Linguagem: Inglês

10.1006/scbi.2000.0332

1096-3650

James R. Berenson, Nelida Sjak-Shie, Robert Vescio,

Lymphoma Diagnosis and Treatment

Multiple myeloma (MM) is characterized by the accumulation of monoclonal plasma cells, a terminally differentiated form of B lymphocyte, in the bone marrow. This disease is most often associated with bone destruction, anemia and renal failure. Besides the malignant plasma cells, it has become clear that nonmalignant cells in the bone marrow also contribute to the development of this malignancy by the release of cytokines. Further support for the importance of the supporting cells comes from our recent finding of the human herpesvirus 8 (HHV-8) in the nonmalignant bone marrow stromal cells from these patients.