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Ocular Toxicity of Diethyltoluamide (Deet)

1984; Informa; Volume: 3; Issue: 1 Linguagem: Inglês

10.3109/15569528409036270

1532-2505

Scott MacRae, Bruce Alan Brown, John L. Ubels, Henry F. Edelhauser, Charlesworth L. Dickerson,

Carcinogens and Genotoxicity Assessment

The ocular toxicity following topical application (10, 30, 100 μl) of 100% DEET, 100% ethanol, and 80% ethanol-20% DEET was evaluated by measuring corneal thickness, area of corneal epithelial damage by fluorescein staining, and corneal reepithelialization. These measurements were compared to the standard toxicological techniques presently used to evaluate eye irritancy. These studies have indicated that corneal thickness, fluorescein staining, and corneal reepithelialization are objective predictors of ocular damage. The 10-μl volume of test substance appeared to be the best volume to predict toxicity, and the corneal reepithelialization studies provided the most accurate method to rank relative toxicity. The current investigation has shown that 100% ethanol is the least toxic followed by 100% DEET and 80% ethanol-20% DEET. Although all test substances showed ocular toxicity, reversibility was obtained by 10 days.