Portal de Periódicos da CAPES

Absence of Cecal Secondary Bile Acids in Gnotobiotic Mice Associated with Two Human Intestinal Bacteria with the Ability to Dehydroxylate Bile Acids In Vitro

1999; Wiley; Volume: 43; Issue: 9 Linguagem: Inglês

10.1111/j.1348-0421.1999.tb01224.x

1348-0421

Seiko Narushima, Kikuji Itoh, Fusae Takamine, Kiyohisa Uchida,

Metabolism and Genetic Disorders

Abstract Germ‐free mice were orally inoculated with human intestinal 7α‐dehydroxylating bacterial strains to evaluate their ability to transform bile acids in vivo . Three weeks after inoculation of the bacteria, cecal bile acids were examined. Among free‐form bile acids, only β‐muricholic acid was detected in the cecal contents of gnotobiotic mice associated with Bacteroides distasonis strain K‐5. No secondary bile acid was observed in the cecal contents of any of the gnotobiotic mice associated with 7α‐dehydroxylating bacteria, Clostridium species strain TO‐931 or Eubacterium species strain 36S.