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CTG triplet repeat expansion in a laryngeal carcinoma from a patient with myotonic dystrophy

2000; Wiley; Volume: 23; Issue: 5 Linguagem: Inglês

10.1002/(sici)1097-4598(200005)23

1097-4598

Ryuichi Osanai, M. Kinoshita, Kazuhiko Hirose, Toshio Homma, Isuzu Kawabata,

Ubiquitin and proteasome pathways

Muscle & NerveVolume 23, Issue 5 p. 804-806 Short Report CTG triplet repeat expansion in a laryngeal carcinoma from a patient with myotonic dystrophy Ryuichi Osanai MD, Corresponding Author Ryuichi Osanai MD oryuichi@saitama-med.ac.jp Department of Otolaryngology, Saitama Medical Center, Saitama Medical School, 1981 Kamoda-Tsujido, Kawagoe, Saitama 350-8550, JapanDepartment of Otolaryngology, Saitama Medical Center, Saitama Medical School, 1981 Kamoda-Tsujido, Kawagoe, Saitama 350-8550, JapanSearch for more papers by this authorMasanobu Kinoshita MD, Masanobu Kinoshita MD Fourth Department of Internal Medicine, Saitama Medical Center, Saitama, JapanSearch for more papers by this authorKazuhiko Hirose MD, Kazuhiko Hirose MD Tokyo Metropolitan Fuchu Hospital, Tokyo, JapanSearch for more papers by this authorToshio Homma MD, Toshio Homma MD Department of Otolaryngology, Saitama Medical Center, Saitama Medical School, 1981 Kamoda-Tsujido, Kawagoe, Saitama 350-8550, JapanSearch for more papers by this authorIsuzu Kawabata MD, Isuzu Kawabata MD Department of Otolaryngology, Saitama Medical Center, Saitama Medical School, 1981 Kamoda-Tsujido, Kawagoe, Saitama 350-8550, JapanSearch for more papers by this author Ryuichi Osanai MD, Corresponding Author Ryuichi Osanai MD oryuichi@saitama-med.ac.jp Department of Otolaryngology, Saitama Medical Center, Saitama Medical School, 1981 Kamoda-Tsujido, Kawagoe, Saitama 350-8550, JapanDepartment of Otolaryngology, Saitama Medical Center, Saitama Medical School, 1981 Kamoda-Tsujido, Kawagoe, Saitama 350-8550, JapanSearch for more papers by this authorMasanobu Kinoshita MD, Masanobu Kinoshita MD Fourth Department of Internal Medicine, Saitama Medical Center, Saitama, JapanSearch for more papers by this authorKazuhiko Hirose MD, Kazuhiko Hirose MD Tokyo Metropolitan Fuchu Hospital, Tokyo, JapanSearch for more papers by this authorToshio Homma MD, Toshio Homma MD Department of Otolaryngology, Saitama Medical Center, Saitama Medical School, 1981 Kamoda-Tsujido, Kawagoe, Saitama 350-8550, JapanSearch for more papers by this authorIsuzu Kawabata MD, Isuzu Kawabata MD Department of Otolaryngology, Saitama Medical Center, Saitama Medical School, 1981 Kamoda-Tsujido, Kawagoe, Saitama 350-8550, JapanSearch for more papers by this author First published: 24 April 2000 https://doi.org/10.1002/(SICI)1097-4598(200005)23:5 3.0.CO;2-ECitations: 16AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract A 66-year-old Japanese man with myotonic dystrophy (DM) underwent total laryngectomy for laryngeal carcinoma. The size of the expanded DNA fragment (EF) from the leukocytes and normal laryngeal tissues of this patient was only slightly longer than that in normal subjects. EF, however, was markedly longer in the laryngeal carcinoma. These findings support the hypothesis that elongation of the CTG repeat in the DM kinase gene occurs during acquired cell proliferation. © 2000 John Wiley & Sons, Inc. Muscle Nerve 23: 804–806, 2000 Citing Literature Volume23, Issue5May 2000Pages 804-806 RelatedInformation