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Expression of Nanog gene promotes NIH3T3 cell proliferation

2005; Elsevier BV; Volume: 338; Issue: 2 Linguagem: Inglês

10.1016/j.bbrc.2005.10.071

1090-2104

Jingyu Zhang, Xia Wang, Bing Chen, Guangli Suo, Yanhong Zhao, Ziyuan Duan, Jianwu Dai,

Renal and related cancers

Cells are the functional elements in tissue engineering and regenerative medicine. A large number of cells are usually needed for these purposes. However, there are numbers of limitations for in vitro cell proliferation. Nanog is an important self-renewal determinant in embryonic stem cells. However, it remains unknown whether Nanog will influence the cell cycle and cell proliferation of mature cells. In this study, we expressed Nanog in NIH3T3 cells and showed that expression of Nanog in NIH3T3 promoted cells to enter into S phase and enhanced cell proliferation. This suggests that Nanog gene might function in a similar fashion in mature cells as in ES cells. In addition, it may provide an approach for in vitro cell expansion.