Enzymatic properties of the one-and two-chain form of tissue plasminogen activator
1982; Elsevier BV; Volume: 27; Issue: 2 Linguagem: Inglês
10.1016/0049-3848(82)90197-9
ISSN1879-2472
AutoresMats Rånby, Nils Bergsdorf, Torbjörn Nilsson,
Tópico(s)Peptidase Inhibition and Analysis
ResumoThe properties of the one-chain and two-chain forms of the porcine tissue plasminogen activator have been compared with respect to their amidolytic activities against a low molecular weight synthetic substrate, and their inhibition by diisopropylphosphofluoridate, α2-antiplasmin and C1-esterase inhibitor. The two-chain form is the more efficient catalyst, and is more rapidly inhibited by diisopropylphosphofluoridate and α2-antiplasmin. Physiological implications are discussed.
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