Portal de Periódicos da CAPES

Primary carcinoma of the liver

1948; Elsevier BV; Volume: 5; Issue: 4 Linguagem: Inglês

10.1016/0002-9343(48)90106-5

1555-7162

Howard L. Holley, Gray Pierson,

RNA modifications and cancer

S INCE the time of Virchow, primary carcinoma of the liver has been considered rare. During the past eighteen months we have observed five cases in approximately 500 consecutive cases autopsied at the School of Medicine of the IJniversity of Alabama. The difficulty in arriving at a reliable diagnosis of this disease has prompted us to discuss only those cases proved at autopsy. The incidence of 1 per cent in our small series is one of the highest recorded occurring in inhabitants of the western world. Counsellor and McIndoe’ give the incidence of primary carcinoma of the liver in 42,276 autopsies as 0.14 per cent. Fox and Bartels2 found this disease in 0.133 per cent of the subjects in 29,215 necropsies. White3 records an incidence of 0.13. per cent in 18,500 autopsies at Guy’s Hospital, London. Goldzieher and Bokay4 and Fried5 report a somewhat higher incidence, 0.3 per cent, the first in a study of 6,000 and the latter in 1,200 autopsies. Strong and Pitts6 report a total incidence of 0.61 per cent in 1,967 autopsies in Vancouver, British Columbia. In the latter report, however, there were ten cases of the disease in 139 Chinese patients who came to autopsy, an incidence of 7.19 per cent. Rosenthal’ records that in 2,091 autopsies a.t Cook County Hospital, Chicago, during 1929 to 1935, there were twelve cases of primary carcinoma of the liver, or 0.57 per cent. Rowan and Mallory8 report nine in 6,500 autopsies, or 0.13 per cent; Clawson and Cabot9 five in 5,100 autopsies, or 0.09 per cent and Torland’O ten in 6,000 autopsies, or 0.16 per cent. The literature shows the tumor in an average of 0.5 per cent of cases coming to autopsy. The incidence of primary carcinoma of Baltimore, Maryland