Portal de Periódicos da CAPES

Modafinil and Cocaine Interactions

2006; Taylor & Francis; Volume: 32; Issue: 4 Linguagem: Inglês

10.1080/00952990600920425

1097-9891

Robert Malcolm, Karla Swayngim, Jennifer L. Donovan, C. Lindsay DeVane, Ahmed Elkashef, Nora Chiang, Roberta Khan, Jurij Mojsiak, Donald L. Myrick, Sarra Hedden, Kristi Cochran, Robert F. Woolson,

Forensic Toxicology and Drug Analysis

This Phase I trial evaluated the interaction between modafinil steady-state and cocaine. Twelve non-treatment seeking, cocaine dependent volunteers received four sets of randomized blinded infusions of saline, 20 mg IV cocaine, and 40 mg IV cocaine. Modafinil was given open label at 0 mg, 400 mg, or 800 mg. Modafinil combined with IV cocaine did not result in any significant hemodynamic interactions. Modafinil significantly dampened scores on Visual Analog Scale measures as compared to baseline cocaine conditions. No significant alterations in labs occurred. Further outpatient trials of modafinil appear to be warranted.