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Functions of the centromere and kinetochore in chromosome segregation

2013; Elsevier BV; Volume: 25; Issue: 3 Linguagem: Inglês

10.1016/j.ceb.2013.02.001

1879-0410

Frederick G. Westhorpe, Aaron F. Straight,

Genomics and Chromatin Dynamics

Centromeres play essential roles in equal chromosome segregation by directing the assembly of the microtubule binding kinetochore and serving as the cohesion site between sister chromatids. Here, we review the significant recent progress in our understanding of centromere protein assembly and how centromere proteins form the foundation of the kinetochore.