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Labdanecaryophyllic acid, a novel cytotoxic C35 terpenoid from Calocedrus macrolepis var. formosana

2010; Elsevier BV; Volume: 52; Issue: 4 Linguagem: Inglês

10.1016/j.tetlet.2010.11.101

1873-3581

Chin‐Lin Hsien, Mei-Hwei Tseng, Ryh‐Nan Pan, Jang‐Yang Chang, Ching‐Chuan Kuo, Tzong‐Huei Lee, Yueh‐Hsiung Kuo,

Cancer Treatment and Pharmacology

Chemical investigation of the bark of Calocedrus macrolepis var. formosana, an endemic tree in Taiwan, has led to the isolation of a novel terpenoid 1. Compound 1 with a rare C35 skeleton constructed by a diterpene and a sesquiterpene moieties. Its structure was elucidated by spectroscopic interpretations. The anti-proliferation activity of 1 against human oral epidermoid carcinoma KB cells was evaluated, and the IC50 value was determined to be 9.2 ± 0.4 μM.