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Salmonella Modulates B Cell Biology to Evade CD8+ T Cell-Mediated Immune Responses

2014; Frontiers Media; Volume: 5; Linguagem: Inglês

10.3389/fimmu.2014.00586

1664-3224

Marcela López‐Medina, Araceli Pérez-López, Celia Alpuche‐Aranda, Vianney Ortiz‐Navarrete,

Salmonella and Campylobacter epidemiology

Although B cells and antibodies are the central effectors of humoral immunity, B cells can also produce and secrete cytokines and present antigen to helper T cells. The uptake of antigen is mainly mediated by endocytosis; thus, antigens are often presented by MHC-II molecules. However, it is unclear if B cells can present these same antigens via MHC-I molecules. Recently, Salmonella bacteria were found to infect B cells, allowing possible antigen cross-processing that could generate bacterial peptides for antigen presentation via MHC-I molecules. Here, we will discuss available knowledge regarding Salmonella antigen presentation by infected B cell MHC-I molecules and subsequent inhibitory effects on CD8+ T cells for bacterial evasion of cell-mediated immunity.