Produção Nacional
Revisado por pares
Use of magnetic resonance to study biodistribution of dextran-coated magnetic fluid intravenously administered in mice
2002; Elsevier BV; Volume: 252; Linguagem: Inglês
10.1016/s0304-8853(02)00654-6
ISSN1873-4766
AutoresL.M. Lacava, Z.G.M. Lacava, Ricardo Bentes Azevedo, Sacha Braun Chaves, Velia Garcia, O Silva, F. Pelegrini, N. Buske, C. Gansau, M.F Da Silva, P.C. Morais,
Tópico(s)Nanoparticle-Based Drug Delivery
ResumoMagnetic resonance was used to investigate the kinetic disposition and the subsequent biodistribution of dextran-coated magnetite nanoparticles (9.4 nm core diameter) after intravenous injection of a bolus dose in female Swiss mice. The X-band spectra show a broad single-line at g≈2, typical of nanomagnetic particles suspended in a non-magnetic matrix. In the first 90 min the time-decay of the nanoparticle concentration in the bloodstream follows the one-exponential (one-compartment) model with a half-life of 6.9 min. With respect to blood the clearance (90 μl/min) and the volume of distribution (900 μl) were obtained from the magnetic resonance data. Magnetite nanoparticles were found 90 min after administration in liver and spleen with a typical absorption half-life of 14 min.
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