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Effects of DDAVP, a vasopressin analog, on delayed matching behavior in the pigeon

1982; Elsevier BV; Volume: 17; Issue: 6 Linguagem: Inglês

10.1016/0091-3057(82)90106-x

1873-5177

Janice J. Teal, Hugh L. Evans,

Neonatal and fetal brain pathology

Five pigeons were tested in a delayed matching-to-sample task after receiving an acute injection of DDAVP(1-desamino-8-D-arginine), scopolamine or d-amphetamine. A feeding test also was used to document non-specific drug effects. Scopolamine produced a marked dose-related decrement in accuracy of matching, regardless of delay, indicating that scopolamine impairs both discrimination and short-term memory. Neither DDAVP nor d-amphetamine produced consistent changes in delayed matching. Thus, an experimental model of short-term memory with pigeons did not confirm the findings of others of a positive effect of DDAVP upon cognitive performance in humans.